Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Revex, Selincro
Nalmefene is an opioid antagonist used to reduce alcohol consumption in individuals with alcohol dependence. It works by blocking the opioid receptors in the brain, reducing the pleasurable effects of alcohol and decreasing cravings. It belongs to a class of medications called opioid antagonists and specifically binds to the μ-opioid receptor.
Reduces alcohol consumption in patients with alcohol dependence.
Outcome:
Reduced opioid efficacy, precipitated withdrawal
Mechanism:
Competitive antagonism at opioid receptors.
Outcome:
Additive CNS depression
Mechanism:
Synergistic effects on CNS function.
Outcome:
Potential decreased effectiveness of nalmefene
Mechanism:
Caffeine may stimulate opioid receptors.
Most likely new formulation: Extended-release nalmefene implant (Year: 2026, 65% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of nalmefene remaining a first-line treatment for alcohol dependence in the next 5 years.
Opioid Antagonist
Morphinan Derivative