Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Prostigmin, Bloxiverz
Neostigmine is a cholinesterase inhibitor, meaning it prevents the breakdown of acetylcholine, a neurotransmitter. This leads to increased acetylcholine levels at the neuromuscular junction, improving nerve impulse transmission to muscles. It's used to treat myasthenia gravis, a condition characterized by muscle weakness, and to reverse the effects of certain muscle relaxants used during surgery. Neostigmine belongs to the class of parasympathomimetic drugs.
For treating myasthenia gravis and reversing the effects of certain muscle relaxants used during surgery.
Outcome:
Prolonged neuromuscular blockade
Mechanism:
Additive effects on acetylcholine receptors.
Outcome:
Reduced efficacy of neostigmine
Mechanism:
Atropine antagonizes cholinergic effects.
Outcome:
Increased muscle weakness
Mechanism:
Quinidine has some neuromuscular blocking activity.
Most likely new formulation: Extended-release oral formulation (Year: 2026, 30% confidence)
Based on current usage trends and clinical trial activity, there is a low (5%) likelihood of a major regulatory change for neostigmine in the next 5 years.
Cholinesterase Inhibitor, Parasympathomimetic
Carbamate