Medicines
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Discover all available medicines and treatments
Brand: Macrobid, Macrodantin, Furadantin, Nitrofurantoin monohydrate/macrocrystals, Nitrofurantoin macrocrystals
Nitrofurantoin is an antibiotic used to treat urinary tract infections (UTIs). It belongs to the class of nitrofurans and works by damaging bacterial DNA, preventing their growth and multiplication. It is effective against a range of common UTI-causing bacteria.
For the treatment of uncomplicated urinary tract infections.
Outcome:
Increased risk of nitrofurantoin toxicity
Mechanism:
Probenecid inhibits renal excretion of nitrofurantoin.
Outcome:
Reduced absorption of nitrofurantoin
Mechanism:
Antacids increase the pH of the stomach, reducing nitrofurantoin absorption.
Outcome:
Potential reduced efficacy of oral contraceptives
Mechanism:
Possible alteration of gut flora.
Most likely new formulation: extended-release oral formulation (Year 2025, 60% confidence)
Based on increasing antibiotic resistance patterns, the likelihood of nitrofurantoin retaining its efficacy against common uropathogens is 75% over the next 5 years.
Antibiotic, Nitrofuran
Nitrofuran