Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Primolut N, Aygestin, Micronor, Noriday, Utovlan
Norethisterone, also known as norethindrone, is a synthetic progestogen used in various hormonal contraceptives and hormone replacement therapy. It belongs to the 19-nortestosterone group of steroids and acts primarily by binding to progesterone receptors, mimicking the effects of the natural hormone progesterone. It's used to treat conditions such as endometriosis, abnormal uterine bleeding, and as a component of combined oral contraceptives to prevent pregnancy.
Used in hormonal contraceptives, hormone replacement therapy, and to treat endometriosis and abnormal uterine bleeding.
Outcome:
Reduced contraceptive efficacy
Mechanism:
Enzyme induction
Outcome:
Increased norethisterone levels
Mechanism:
CYP3A4 inhibition
Outcome:
Potentially reduced norethisterone absorption
Mechanism:
Changes in gastric pH
Most likely new formulation: Extended-release implant (Year 2026, 75% confidence)
Based on current usage trends and clinical trial data, there is a 90% likelihood of norethisterone remaining a first-line treatment for endometriosis in the next 5 years.
Progestin, Steroid Hormone
19-Nortestosterone Derivative