Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Pamelor, Aventyl, Norventyl
Nortriptyline is a tricyclic antidepressant (TCA) primarily used to treat major depressive disorder. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. These neurotransmitters are involved in regulating mood, sleep, and other bodily functions. Nortriptyline is also sometimes used to treat other conditions, such as nerve pain and migraines.
For treating major depressive disorder, nerve pain, and migraines.
Suicidal thoughts or actions in children, adolescents, and young adults.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Increased blood pressure
Mechanism:
Inhibition of antihypertensive effect
Outcome:
Slightly increased bleeding risk
Mechanism:
Inhibition of platelet aggregation
Most likely new formulation: Extended-release formulation for improved patient compliance (2025, 60% confidence).
Based on current usage trends and clinical trial data, there is a low probability of any major regulatory changes for nortriptyline in the next 5 years (less than 5% likelihood).
Tricyclic Antidepressant
Dibenzocycloheptadiene