Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Osphena
Ospemifene is a selective estrogen receptor modulator (SERM) primarily used to treat moderate to severe dyspareunia (painful sexual intercourse), a symptom of vulvar and vaginal atrophy (VVA) due to menopause. It acts like estrogen in some tissues, such as the vagina, while blocking estrogen's effects in others, such as the breast and uterus. This targeted action helps to restore vaginal tissue and reduce pain during intercourse without increasing the risk of estrogen-related side effects in other parts of the body.
For the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy due to menopause.
Outcome:
Increased risk of estrogenic side effects (e.g., endometrial hyperplasia)
Mechanism:
Additive estrogenic effects
Outcome:
Potential additive effects on lipid profiles
Mechanism:
Shared metabolic pathways
Outcome:
Potential decreased absorption of ospemifene
Mechanism:
Altered gastric pH
Most likely new formulation: Transdermal patch (Year: 2026, 70% confidence)
Based on current usage trends and safety profile, ospemifene is expected to maintain its current regulatory status for the foreseeable future (90% confidence).
Selective Estrogen Receptor Modulator (SERM)
Triarylalkene