Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Taxol, Abraxane
Paclitaxel is a chemotherapy medication used to treat various types of cancer. It belongs to the taxane class of drugs, derived from the Pacific yew tree. Paclitaxel works by interfering with cell division, specifically targeting microtubules, which are essential for cell structure and function. This disruption inhibits cancer cells from growing and spreading.
Used to treat ovarian, breast, lung, Kaposi's sarcoma, and other cancers.
Severe hypersensitivity reactions, including anaphylaxis, have occurred. Premedication is required.
Outcome:
Increased paclitaxel toxicity
Mechanism:
Inhibition of paclitaxel metabolism
Outcome:
Increased paclitaxel toxicity
Mechanism:
CYP3A4 inhibition
Outcome:
Reduced paclitaxel absorption
Mechanism:
Altered gastrointestinal pH
Most likely new formulation: Nanoparticle delivery system (2025, 80% confidence)
Based on current clinical trial activity, there is a 70% likelihood of a new paclitaxel formulation being approved in the next 5 years.
Antineoplastic, Antimicrotubule Agent, Taxane
Taxane