Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Invega, Invega Sustenna, Invega Trinza, Xeplion, Trevicta
Paliperidone is an atypical antipsychotic primarily used to treat schizophrenia and schizoaffective disorder. It is the active metabolite of risperidone and acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, along with other receptor interactions. Its extended-release formulation allows for once-daily dosing.
For the treatment of schizophrenia and schizoaffective disorder.
Increased mortality in elderly patients with dementia-related psychosis treated with antipsychotic drugs.
Outcome:
Reduced paliperidone levels
Mechanism:
CYP3A4 induction
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects
Outcome:
Reduced paliperidone absorption
Mechanism:
Chelation
Most likely new formulation: Long-acting injectable with improved tolerability (2025, 80% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of expanded indications for paliperidone in the next 5 years.
Atypical Antipsychotic
Benzisoxazole derivative