Medicines
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Discover all available medicines and treatments
Brand: Aloxi, Onicit
Palonosetron is a highly selective 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting caused by chemotherapy. It belongs to the serotonin receptor antagonist class and works by blocking the action of serotonin, a neurotransmitter involved in the vomiting reflex. Palonosetron has a longer half-life than other 5-HT3 antagonists, allowing for single-dose administration in many cases.
For prevention of nausea and vomiting associated with chemotherapy.
Outcome:
Reduced antiemetic efficacy of palonosetron
Mechanism:
Pharmacodynamic interaction
Outcome:
Additive antiemetic effect
Mechanism:
Pharmacodynamic synergism
Outcome:
May slightly decrease palonosetron absorption
Mechanism:
Altered gastric pH
Most likely new formulation: Extended-release oral formulation (Year 2026, 70% confidence)
Based on current usage trends and clinical trial data, there is a 90% likelihood that palonosetron will maintain its current FDA approval status for the next 5 years.
Serotonin 5-HT3 Receptor Antagonist, Antiemetic
Setron