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Brand: Aredia
Pamidronate is a bisphosphonate medication primarily used to treat conditions characterized by excessive bone breakdown, such as Paget's disease of bone, hypercalcemia of malignancy (high blood calcium levels due to cancer), and bone metastases (cancer that has spread to the bones). It belongs to the class of drugs known as bone resorption inhibitors. Pamidronate works by inhibiting the action of osteoclasts, cells responsible for breaking down bone tissue. This helps to reduce bone turnover and maintain bone density.
For Paget's disease of bone, hypercalcemia of malignancy, and bone metastases.
Outcome:
Increased risk of hypocalcemia
Mechanism:
Additive effects on calcium lowering
Outcome:
Reduced absorption of pamidronate
Mechanism:
Chelation of pamidronate by antacids
Outcome:
Reduced absorption of pamidronate
Mechanism:
Binding of pamidronate to food components
Most likely new formulation: Extended-release pamidronate (Year 2026, 75% confidence)
Based on usage trends and clinical trial outcomes, there is a 90% likelihood that pamidronate will maintain its current FDA approval status for the next 5 years.
Bisphosphonate, Bone Resorption Inhibitor
Bisphosphonate