Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Humatin, Aminosidine
Paromomycin is an aminoglycoside antibiotic used to treat certain parasitic infections, primarily intestinal amebiasis and leishmaniasis. It works by inhibiting protein synthesis in the parasite, leading to its death. Paromomycin is poorly absorbed orally, making it effective against intestinal parasites but requiring alternative routes of administration for systemic infections like visceral leishmaniasis.
For the treatment of intestinal amebiasis, cryptosporidiosis in immunocompromised patients, and visceral leishmaniasis.
Outcome:
Increased risk of kidney damage
Mechanism:
Additive nephrotoxicity
Outcome:
Increased risk of nephrotoxicity and ototoxicity
Mechanism:
Enhanced drug elimination
Outcome:
Reduced absorption of paromomycin
Mechanism:
Binding in the gut
Most likely new formulation: Liposomal paromomycin for improved visceral leishmaniasis treatment (Year: 2028, 60% confidence)
Based on current usage trends and research activity, there is a low ( < 10%) likelihood of major regulatory changes for paromomycin in the next 5 years.
Antibiotic, Antiparasitic
Aminoglycoside