Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Levatol
Penbutolol is a beta-adrenergic blocking agent, or beta-blocker, primarily used to treat high blood pressure (hypertension). It belongs to the class of beta-1 selective blockers, meaning it preferentially blocks the beta-1 receptors found in the heart. This action reduces heart rate and cardiac output, which contributes to lowering blood pressure. It also possesses some intrinsic sympathomimetic activity (ISA), which may prevent excessive slowing of the heart rate.
For the treatment of hypertension.
Outcome:
Severe bradycardia and hypotension
Mechanism:
Additive effects on heart rate and blood pressure.
Outcome:
Reduced antihypertensive effect
Mechanism:
NSAIDs can reduce the effectiveness of beta-blockers.
Outcome:
Reduced antihypertensive effect
Mechanism:
Caffeine can stimulate the cardiovascular system.
Most likely new formulation: Extended-release formulation to improve patient compliance (Year: 2026, 60% confidence)
Based on current usage trends and the availability of newer antihypertensive agents, the market share of penbutolol is predicted to decline by 5% over the next 5 years.
Beta-blocker, Beta-1 selective blocker
Aryloxypropanolamine