Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Trental, Pentoxil, Flexital
Pentoxifylline is a xanthine derivative that improves blood flow by decreasing blood viscosity (thickness) and improving red blood cell deformability. It is used to treat intermittent claudication, a symptom of peripheral artery disease (PAD). It belongs to the class of hemorrheologic agents.
Used to improve blood flow in patients with intermittent claudication caused by peripheral artery disease.
Outcome:
Increased risk of theophylline toxicity
Mechanism:
Pentoxifylline can inhibit the metabolism of theophylline.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Additive effects on gastrointestinal mucosa.
Outcome:
May slightly delay absorption
Mechanism:
Not fully elucidated.
Most likely new formulation: Extended-release formulation to improve patient compliance (Year: 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a low ( <5%) likelihood of a significant change in regulatory status within the next 5 years.
Hemorrheologic Agent, Vasodilator
Xanthine Derivative