Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Picato
PEP005, also known as ingenol mebutate, is a diterpene ester derived from the sap of the plant Euphorbia peplus. It is used topically for the treatment of actinic keratosis (AK), a precancerous skin condition caused by sun exposure. PEP005 belongs to the class of small molecule drugs and functions by inducing cell death and inflammation in the targeted AK lesions.
For topical treatment of actinic keratosis.
Outcome:
Increased irritation or adverse reactions
Mechanism:
Additive effect on skin irritation
Outcome:
Increased skin irritation
Mechanism:
Additive effect on skin cell turnover
Outcome:
May reduce itching associated with treatment
Mechanism:
Antihistamine effect
Unlikely to see new formulations of ingenol mebutate due to safety profile (0% confidence).
Due to safety concerns and market withdrawal, there is a 0% likelihood of renewed FDA approval for PEP005 in its current formulation.
Antineoplastic Agent, Keratolytic
Diterpene Ester