Medicines
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Discover all available medicines and treatments
Brand: Permax
Pergolide is a dopamine agonist primarily used in the treatment of Parkinson's disease. It belongs to the ergoline class of drugs and acts by mimicking the effects of dopamine in the brain, helping to alleviate symptoms like tremors, rigidity, and bradykinesia. However, its use has declined significantly due to concerns about cardiac valvulopathy.
For the treatment of Parkinson's disease symptoms.
Outcome:
Reduced efficacy of pergolide
Mechanism:
Pharmacodynamic antagonism
Outcome:
Increased risk of hypotension
Mechanism:
Additive hypotensive effects
Outcome:
May decrease pergolide absorption
Mechanism:
Chelation
No significant innovation is expected for pergolide due to its withdrawal and safety concerns.
Due to its withdrawal, the likelihood of pergolide's reintroduction to the market is extremely low (<1%).
Dopamine Agonist, Ergot Alkaloid
Ergoline Derivative