Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Coversyl, Aceon
Perindoprilat is the active metabolite of perindopril, an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reduced blood volume, and decreased peripheral vascular resistance, ultimately lowering blood pressure.
For treating hypertension (high blood pressure), heart failure, and stable coronary artery disease.
Fetal toxicity: Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potentially reversible neonatal renal failure, hypotension, and hyperkalemia have been reported in association with maternal use of ACE inhibitors.
Outcome:
Hyperkalemia
Mechanism:
Reduced potassium excretion
Outcome:
Hypotension
Mechanism:
Additive effects on blood pressure
Outcome:
Slightly reduced absorption
Mechanism:
Unknown
Most likely new formulation: Combination therapy with other antihypertensives (2024, 70% confidence)
Based on current usage trends and clinical trial data, there is a low probability ( <5%) of perindoprilat being withdrawn from the market in the next 5 years.
ACE Inhibitor
Non-sulfhydryl-containing ACE inhibitor