Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Trilafon, Fentazin
Perphenazine is a first-generation antipsychotic medication belonging to the phenothiazine class. It primarily works by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. It is also sometimes used to treat severe nausea and vomiting.
For the treatment of schizophrenia and other psychotic disorders, as well as for severe nausea and vomiting.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Outcome:
Increased sedation and dizziness
Mechanism:
Additive CNS depression
Outcome:
Reduced absorption of perphenazine
Mechanism:
Chelation
Outcome:
Delayed absorption
Mechanism:
Decreased gastric emptying
Most likely new formulation: Extended-release oral formulation (Year: 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a low ( <5%) likelihood of regulatory changes regarding Perphenazine’s approved indications in the next 2 years.
Antipsychotic, Antiemetic
Piperazinyl phenothiazine