Medicines
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Discover all available medicines and treatments
Brand: Cervidil, Prepidil, Prostin E2
Prostaglandin E2 (PGE2) is a naturally occurring prostaglandin with diverse physiological roles. It plays a crucial role in inflammation, pain, fever, and ovulation. It also has effects on smooth muscle contraction in the gastrointestinal tract, respiratory system, and uterus. Synthetic PGE2 is used medically for various purposes, including inducing labor, terminating pregnancy, and maintaining patency of the ductus arteriosus in newborns with congenital heart defects.
Used for labor induction, cervical ripening, abortion, and maintaining ductus arteriosus patency in neonates.
Outcome:
Increased risk of uterine rupture
Mechanism:
Synergistic effect on uterine contractions
Outcome:
Reduced efficacy of PGE2
Mechanism:
Inhibition of prostaglandin synthesis
Outcome:
No significant interaction expected
Mechanism:
Different mechanisms of action
Most likely new formulation: Controlled-release vaginal insert for cervical ripening (2025, 70% confidence)
Based on current usage trends and safety profile, PGE2 is likely to maintain its approved status for current indications (95% confidence).
Prostaglandin
Eicosanoid