Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Nardil
Phenelzine is a monoamine oxidase inhibitor (MAOI) primarily used to treat atypical depression, a subtype of major depressive disorder. It works by preventing the breakdown of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain, thereby increasing their levels. Belonging to the hydrazine class of MAOIs, phenelzine is known for its effectiveness in treating depression with anxiety, phobias, and hypochondriasis but requires a strict dietary regimen due to potential interactions with tyramine-rich foods and certain medications. It is generally reserved for cases where other antidepressant treatments have been unsuccessful.
For treating atypical depression, anxiety disorders, and bulimia.
Phenelzine carries a black box warning for the risk of hypertensive crisis when taken with tyramine-containing foods or certain medications. It also warns against the risk of suicidal thoughts and behaviors in young adults and children.
Outcome:
Hypertensive crisis
Mechanism:
Increased tyramine levels due to MAO inhibition
Outcome:
Hypertension
Mechanism:
Possible synergistic effect on serotonin receptors
Outcome:
Increased anxiety, insomnia
Mechanism:
Additive stimulant effects
Most likely new formulation: Transdermal patch (Year: 2028, 30% confidence)
Based on current usage trends and emerging therapies, there is a low (5%) likelihood of new regulatory restrictions on phenelzine in the next 5 years.
Monoamine Oxidase Inhibitor (MAOI), Antidepressant
Hydrazine