Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Dibenzyline
Phenoxybenzamine is a non-selective, irreversible alpha-adrenergic antagonist used primarily to control hypertension caused by pheochromocytoma. It belongs to the class of drugs known as alpha-blockers and works by blocking the effects of norepinephrine, a hormone that constricts blood vessels. This leads to vasodilation and a decrease in blood pressure. It's crucial to note that its irreversible binding can lead to prolonged effects, requiring careful dosage adjustments.
For the treatment of hypertension caused by pheochromocytoma, peripheral vascular diseases like Raynaud's phenomenon, and frostbite.
Outcome:
Reduced effectiveness of epinephrine
Mechanism:
Alpha-adrenergic blockade inhibits epinephrine's vasoconstricting effects.
Outcome:
Additive hypotensive effects
Mechanism:
Both substances lower blood pressure through different mechanisms.
Outcome:
Potential slight decrease in phenoxybenzamine effectiveness
Mechanism:
Caffeine can have mild vasoconstricting effects.
Most likely new formulation: Extended-release formulation for improved patient compliance (Year 2025, 70% confidence).
Based on current usage trends and ongoing research into alternative treatments, there is a 20% likelihood of stricter regulations on phenoxybenzamine prescribing within the next 5 years.
Alpha-adrenergic antagonist, Antihypertensive
Haloalkylamine