Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Antilirium, Isopto Eserine
Physostigmine is a cholinesterase inhibitor, meaning it prevents the breakdown of acetylcholine, a neurotransmitter. This leads to increased acetylcholine levels in the synapses, enhancing cholinergic activity. It is used to treat anticholinergic poisoning, glaucoma, and delayed gastric emptying. Physostigmine belongs to the class of reversible cholinesterase inhibitors.
For treating anticholinergic poisoning, glaucoma, and delayed gastric emptying.
Outcome:
Reduced effectiveness of physostigmine
Mechanism:
Competitive antagonism at muscarinic receptors.
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects.
Outcome:
May decrease the effectiveness of physostigmine
Mechanism:
Caffeine has mild anticholinergic properties.
Most likely new formulation: Transdermal patch for improved drug delivery (Year: 2026, 60% confidence)
Based on historical data and current usage trends, there is a low probability (less than 5%) of any major regulatory changes for physostigmine in the next 5 years.
Cholinesterase Inhibitor, Parasympathomimetic
Indole Alkaloid