Medicines
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Discover all available medicines and treatments
Brand: Pixuvri
Pixantrone is an antineoplastic agent, specifically an aza-anthracenedione, used in the treatment of relapsed or refractory aggressive non-Hodgkin B-cell lymphoma. It acts by intercalating into DNA, disrupting DNA synthesis and function, leading to cell death. It is considered less cardiotoxic than other anthracyclines like doxorubicin.
For the treatment of relapsed or refractory aggressive non-Hodgkin B-cell lymphoma.
Outcome:
Increased pixantrone exposure
Mechanism:
Reduced pixantrone metabolism
Outcome:
Potentially increased pixantrone exposure
Mechanism:
Partially reduced pixantrone metabolism
Outcome:
Slightly increased pixantrone absorption
Mechanism:
Enhanced solubility in the presence of fats
Most likely new formulation: Liposomal pixantrone for improved delivery and reduced toxicity (2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of pixantrone being repurposed for other indications in the next 5 years.
Antineoplastic, Aza-anthracenedione
Aza-anthracenedione