Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Sandomigran, Mosegor, Sanomigran
Pizotifen is a serotonin antagonist and antihistamine used primarily for migraine prophylaxis. It belongs to the class of drugs known as tricyclic benzocycloheptathiophenes. Pizotifen is thought to work by blocking serotonin receptors, stabilizing mast cells, and potentially inhibiting calcium channels. This multifaceted action helps to reduce the frequency and severity of migraine attacks.
For migraine prophylaxis.
Outcome:
Increased drowsiness and impaired coordination
Mechanism:
Additive CNS depressant effects
Outcome:
Additive hypotensive effects
Mechanism:
Both drugs can lower blood pressure
Outcome:
May decrease the effectiveness of pizotifen
Mechanism:
Caffeine is a stimulant
Most likely new formulation: Extended-release formulation (Year: 2026, 30% confidence)
Based on current usage patterns and clinical trial data, there is a low probability (<10%) of FDA approval for pizotifen in the next 5 years.
Serotonin antagonist, Antihistamine
Tricyclic benzocycloheptathiophene