Medicines
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Discover all available medicines and treatments
Brand: Aerosporin, Polymyxin B Sulfate
Polymyxin B is an antibiotic primarily used to treat multidrug-resistant gram-negative bacterial infections. It belongs to the polymyxin class of antibiotics, which are cationic detergents that disrupt the bacterial cell membrane. It is particularly effective against bacteria like *Pseudomonas aeruginosa* and *Acinetobacter baumannii*. Due to its potential for nephrotoxicity and neurotoxicity, systemic use is generally reserved for serious infections where other antibiotics are ineffective.
For treating serious, multidrug-resistant gram-negative bacterial infections.
Outcome:
Increased risk of nephrotoxicity.
Mechanism:
Additive nephrotoxic effects.
Outcome:
Increased risk of nephrotoxicity.
Mechanism:
Additive effects on renal function.
Outcome:
Reduced absorption of polymyxin.
Mechanism:
Binding of polymyxin in the gastrointestinal tract.
Most likely new formulation: inhaled polymyxin for lung infections (2025, 70% confidence)
Based on increasing resistance to other antibiotics, polymyxin B use is predicted to increase by 15% in the next 5 years.
Antibiotic, Polymyxin
Polypeptide Antibiotic