Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Mysoline, Prysoline, Mylepsin, Primaclone, Liskantin
Primidone is an anticonvulsant medication used to treat various types of seizures, including tonic-clonic seizures, complex partial seizures, and myoclonic seizures. It is structurally related to barbiturates but has a distinct mechanism of action. Primidone is metabolized in the liver to phenobarbital and phenylethylmalonamide (PEMA), both of which contribute to its anticonvulsant effects.
Primidone is used to treat various types of seizures, including tonic-clonic seizures, complex partial seizures, and myoclonic seizures.
Outcome:
Increased sedation and CNS depression
Mechanism:
Additive CNS depressant effects
Outcome:
Decreased doxycycline effectiveness
Mechanism:
Primidone induces hepatic enzymes that metabolize doxycycline.
Outcome:
Slight decrease in primidone absorption
Mechanism:
Altered pH in the stomach.
Most likely new formulation: Extended-release primidone (2025, 60% confidence)
Based on current usage trends and emerging therapies, there is a 15% likelihood of a generic primidone formulation being discontinued within the next 5 years.
Anticonvulsant, Antiepileptic
Pyrimidinedione