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Brand: Alcaine, Ophthetic
Proparacaine is a local anesthetic used primarily in ophthalmology. It belongs to the ester class of local anesthetics and works by blocking sodium channels, thereby inhibiting nerve impulse transmission and producing a reversible loss of sensation in the area of application. Proparacaine is typically administered as eye drops.
For topical anesthesia of the eye during ophthalmic procedures.
Outcome:
Reduced antibacterial effect of sulfonamides
Mechanism:
Proparacaine may interfere with the action of sulfonamides.
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects.
Outcome:
Potential for reduced analgesic effect of NSAIDs
Mechanism:
May interfere with prostaglandin synthesis.
Most likely new formulation: Extended-release formulation for prolonged anesthesia (Year: 2026, 60% confidence)
Based on current usage patterns and safety profile, proparacaine is expected to maintain its approved status for ophthalmic use.
Local Anesthetic, Ester
Aminoester