Medicines
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Brand: Neuleptil, Periciazine
Propericiazine is a typical antipsychotic medication belonging to the phenothiazine class. It primarily acts by blocking dopamine receptors in the brain, thereby reducing the excessive dopamine activity associated with psychotic disorders like schizophrenia. Propericiazine also exhibits some antihistaminic, anticholinergic, and alpha-adrenergic blocking properties, which contribute to its side effect profile.
For the treatment of psychotic disorders, particularly schizophrenia.
Outcome:
Increased sedation and impaired coordination.
Mechanism:
Additive CNS depressant effects.
Outcome:
Reduced absorption of propericiazine.
Mechanism:
Chelation or altered gastric pH.
Outcome:
May slightly delay absorption.
Mechanism:
Delayed gastric emptying.
Most likely new formulation: Extended-release oral formulation (2025, 30% confidence)
Based on historical data of similar phenothiazines, the likelihood of propericiazine gaining FDA approval is low (<5%).
Antipsychotic, Phenothiazine
Phenothiazine