Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Tomudex
Raltitrexed is an antineoplastic agent, specifically an antifolate, used in the treatment of advanced colorectal cancer. It inhibits the enzyme thymidylate synthase, which is crucial for DNA synthesis, thereby blocking cell division and tumor growth. Raltitrexed is administered intravenously and is often used in combination with other chemotherapeutic agents.
For the treatment of advanced colorectal cancer.
Outcome:
Increased risk of myelosuppression
Mechanism:
Both drugs inhibit dihydrofolate reductase.
Outcome:
Reduced efficacy of raltitrexed
Mechanism:
Folic acid can bypass the inhibition of thymidylate synthase.
Outcome:
Generally safe
Mechanism:
Different mechanism of action
Most likely new formulation: Liposomal raltitrexed for enhanced delivery (2025, 20% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood (<5%) of regulatory changes impacting raltitrexed's availability in the near future.
Antineoplastic, Antifolate
Quinazoline