Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Rapamune, Torisel, Afinitor, Everolimus
Rapamycin, also known as sirolimus, is an immunosuppressant drug used to prevent rejection in organ transplantation, particularly kidney transplants. It belongs to the macrolide class of drugs and works by inhibiting the mammalian target of rapamycin (mTOR), a key protein involved in cell growth and proliferation. This action helps to suppress the immune system and prevent it from attacking the transplanted organ.
Used to prevent organ transplant rejection, treat certain cancers, and manage rare lung diseases.
Increased risk of serious infections, including fungal infections, bacterial infections, and viral infections. Increased risk of lymphoproliferative disorders, including lymphoma and skin cancer. Impaired wound healing.
Outcome:
Increased rapamycin levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Increased rapamycin levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Minimal interaction
Mechanism:
Different metabolic pathways
Most likely new formulation: Extended-release injectable formulation (2025, 80% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of expanded indications for rapamycin in the treatment of age-related diseases within the next 5 years.
Immunosuppressant, mTOR inhibitor
Macrolide