Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Potiga, Trobalt
Retigabine, also known as ezogabine, is an anticonvulsant medication used as an adjunctive therapy for partial-onset seizures in adults. It belongs to a unique class of antiepileptic drugs and works by opening potassium channels in neurons, stabilizing their electrical activity and reducing the likelihood of seizures.
Adjunctive treatment of partial-onset seizures in adults.
Outcome:
Increased retigabine levels
Mechanism:
Inhibition of retigabine metabolism
Outcome:
Increased digoxin levels
Mechanism:
Inhibition of digoxin renal clearance
Outcome:
Slightly decreased retigabine absorption
Mechanism:
Chelation or altered gastric pH
It is unlikely to see new formulations of retigabine due to safety concerns (2024, 95% confidence).
Due to its withdrawal from the market, retigabine has a 0% likelihood of being re-approved in its current formulation.
Anticonvulsant, Potassium Channel Opener
Carboxamide