Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Xifaxan, Normix
Rifaximin is a non-absorbable antibiotic primarily used to treat traveler's diarrhea caused by noninvasive strains of Escherichia coli (E. coli) and to reduce the risk of hepatic encephalopathy recurrence. It belongs to the rifamycin class of antibiotics and works by inhibiting bacterial RNA synthesis. Because it's poorly absorbed into the bloodstream, it stays primarily within the gut, minimizing systemic side effects.
For traveler's diarrhea, hepatic encephalopathy, and irritable bowel syndrome with diarrhea (IBS-D).
Outcome:
Increased risk of bleeding
Mechanism:
Rifaximin may affect the gut flora involved in vitamin K synthesis, potentially altering warfarin's anticoagulant effect.
Outcome:
Additive gastrointestinal effects like nausea and diarrhea
Mechanism:
Not fully established.
Outcome:
Potential for reduced rifaximin absorption
Mechanism:
Changes in stomach pH.
Most likely new formulation: Modified-release formulation for improved patient adherence (Year 2025, 80% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of expanded indications for rifaximin in the next 5 years.
Antibiotic, Rifamycin
Rifamycin