Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Norvir
Ritonavir is an antiretroviral medication primarily used as a pharmacokinetic enhancer for other protease inhibitors in the treatment of HIV/AIDS. It belongs to the protease inhibitor class and works by inhibiting the HIV protease enzyme, which is essential for viral replication. While ritonavir has antiviral activity itself, it's typically used in lower doses to boost the levels of other protease inhibitors, allowing for simplified dosing regimens and improved efficacy. It is not typically used as a standalone treatment due to the rapid development of resistance.
Used as a pharmacokinetic enhancer for other protease inhibitors in the treatment of HIV/AIDS.
Ritonavir can cause serious liver problems, including life-threatening liver failure. Patients with underlying liver disease, including chronic hepatitis B or C, are at increased risk. Liver function tests should be monitored closely. Ritonavir can also cause serious heart rhythm problems, including new onset or worsening of pre-existing heart conditions. It is important to inform your doctor about any heart conditions you may have.
Outcome:
Increased risk of life-threatening heart rhythm problems
Mechanism:
Ritonavir inhibits the metabolism of amiodarone.
Outcome:
Altered anticoagulant effect of warfarin
Mechanism:
Ritonavir may affect the metabolism of warfarin.
Outcome:
Reduced absorption of ritonavir
Mechanism:
Antacids can bind to ritonavir and reduce its absorption.
Most likely new formulation: Long-acting injectable formulation (2025, 70% confidence)
Based on usage trends and clinical trial data, there is a low (<5%) likelihood of ritonavir being withdrawn from the market in the next 5 years.
Antiretroviral, Protease Inhibitor
Peptidomimetic