Medicines
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Discover all available medicines and treatments
Brand: Avandia
Rosiglitazone is an oral antidiabetic drug in the thiazolidinedione class. It works by improving insulin sensitivity in muscle, fat, and liver cells, thereby lowering blood glucose levels. It is primarily used to treat type 2 diabetes, often in combination with other medications like metformin or sulfonylureas when diet and exercise alone are insufficient.
Used to treat type 2 diabetes by improving insulin sensitivity.
May cause or exacerbate congestive heart failure in some patients. Use with caution in patients with known cardiovascular disease.
Outcome:
Increased risk of hypotension
Mechanism:
Additive vasodilatory effects
Outcome:
Decreased rosiglitazone concentrations
Mechanism:
Induction of rosiglitazone metabolism
Outcome:
Potential for fluid retention
Mechanism:
Renal effects
Most likely new formulation: Combination therapy with other antidiabetic agents (Year: Unlikely, <1% confidence)
Based on current usage trends and safety concerns, the likelihood of new restrictions on rosiglitazone use remains low ( <5%).
Antidiabetic, Thiazolidinedione
Thiazolidinedione