Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zocor, Simvacor, Simvastatin Actavis, Simlo, Vastin
Simvastatin is a lipid-lowering medication belonging to the statin class. It works by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol synthesis in the liver. This action reduces the production of LDL cholesterol ("bad" cholesterol) and triglycerides, while modestly increasing HDL cholesterol ("good" cholesterol). Simvastatin is commonly prescribed to manage high cholesterol and reduce the risk of cardiovascular events such as heart attacks and strokes.
For lowering cholesterol levels and reducing the risk of cardiovascular disease.
Outcome:
Increased risk of rhabdomyolysis
Mechanism:
Pharmacokinetic interaction involving CYP3A4 inhibition.
Outcome:
Increased risk of myopathy
Mechanism:
Pharmacokinetic interaction.
Outcome:
Increased simvastatin levels
Mechanism:
Inhibition of CYP3A4 metabolism.
Most likely new formulation: Controlled-release simvastatin with improved patient compliance (Year: 2025, 70% confidence)
Based on current usage trends and ongoing clinical trials, there is a 90% likelihood that simvastatin will maintain its current regulatory status for the next 5 years.
HMG-CoA Reductase Inhibitor, Statin
Statin