Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zagam
Sparfloxacin is a fluoroquinolone antibiotic used to treat bacterial infections. It works by inhibiting DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and repair. It belongs to the broader class of quinolone antibiotics and is known for its broad spectrum of activity against both Gram-positive and Gram-negative bacteria.
For the treatment of community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, and acute sinusitis.
Severe and sometimes fatal reactions, including tendinitis and tendon rupture, peripheral neuropathy, central nervous system effects, and exacerbation of myasthenia gravis, have been reported with fluoroquinolone antibiotics.
Outcome:
Increased theophylline levels, leading to toxicity.
Mechanism:
Sparfloxacin inhibits theophylline metabolism.
Outcome:
Reduced absorption of sparfloxacin.
Mechanism:
Chelation with the didanosine formulation.
Outcome:
May slightly delay absorption.
Mechanism:
Delayed gastric emptying.
Most likely new formulation: extended-release oral formulation (Year 2026, 30% confidence)
Based on historical usage patterns and emerging resistance data, there is a low ( <5%) likelihood of sparfloxacin being withdrawn from the market in the next 5 years.
Antibiotic, Fluoroquinolone
Fluoroquinolone