Medicines
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Discover all available medicines and treatments
Brand: Zerit, Stavudin
Stavudine, commonly known as d4T, is a nucleoside reverse transcriptase inhibitor (NRTI) used in combination with other antiretroviral medications to treat HIV/AIDS. It works by interfering with the virus's ability to replicate itself, thus slowing the progression of the disease. Stavudine is generally no longer recommended as a first-line treatment due to its association with severe side effects like peripheral neuropathy, lipodystrophy, and lactic acidosis.
Used in combination with other antiretroviral medications to treat HIV/AIDS.
Severe peripheral neuropathy, lactic acidosis, severe hepatomegaly with steatosis, and lipodystrophy (including fat loss and redistribution).
Outcome:
Increased risk of lactic acidosis and peripheral neuropathy
Mechanism:
Pharmacokinetic interaction, potentially overlapping toxicity
Outcome:
Increased risk of peripheral neuropathy
Mechanism:
Additive neurotoxicity
Outcome:
May slightly increase stavudine levels
Mechanism:
Competition for renal excretion
Most likely new development related to stavudine would be in improving diagnostic tools for related adverse effects (e.g. peripheral neuropathy), though confidence is low (<5%).
Based on decreasing usage and safety concerns, there is a low (<1%) likelihood of new stavudine formulations being developed.
Antiretroviral, Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Thymidine Nucleoside Analogue