Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zanosar
Streptozotocin is a naturally occurring alkylating antineoplastic agent specifically toxic to the insulin-producing beta cells of the pancreas. It is used in research to induce experimental diabetes in animal models and, less frequently, as a chemotherapy agent for certain types of pancreatic neuroendocrine tumors (islet cell carcinoma). Its mechanism involves DNA alkylation and free radical formation, leading to beta cell death.
Used in research to induce diabetes in animal models and as a chemotherapy agent for certain pancreatic neuroendocrine tumors.
Severe nausea and vomiting. Renal toxicity including acute renal failure and proteinuria. Myelosuppression including thrombocytopenia, anemia and leukopenia. Pulmonary toxicity including fibrosis and interstitial pneumonitis. Secondary malignancies.
Outcome:
Increased risk of kidney damage
Mechanism:
Additive nephrotoxicity
Outcome:
Increased risk of renal impairment
Mechanism:
Additive nephrotoxicity
Outcome:
Potential decreased absorption of streptozotocin
Mechanism:
Changes in gastric pH
Most likely new formulation: Improved targeted delivery systems for pancreatic cancer treatment (2028, 25% confidence)
Based on current research activity, there is a low ( <10%) likelihood of significant regulatory changes for streptozotocin in the next 5 years.
Antineoplastic, Alkylating Agent, Glucosamine-nitrosourea
Glucosamine-nitrosourea