Medicines
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Discover all available medicines and treatments
Brand: Sufenta, Dsuvia
Sufentanil is a potent synthetic opioid analgesic used in surgical settings for its rapid onset and short duration of action. It is classified as a phenylpiperidine derivative and acts as a full opioid agonist, primarily binding to mu-opioid receptors in the central nervous system. This binding inhibits pain signal transmission, leading to analgesia. Due to its high potency, sufentanil requires careful titration and monitoring, and is typically administered by trained anesthesia professionals.
Sufentanil is used for analgesia during surgery and in intensive care settings for pain management.
Sufentanil can cause respiratory depression, especially in elderly, debilitated, or opioid-naive patients. It should be used with caution in patients with impaired respiratory function. High doses can lead to chest wall rigidity, making ventilation difficult. Accidental exposure can be fatal, particularly in children.
Outcome:
Increased respiratory depression, sedation, and hypotension.
Mechanism:
Additive CNS depressant effects.
Outcome:
Increased risk of constipation and urinary retention.
Mechanism:
Additive anticholinergic effects.
Outcome:
Decreased sufentanil efficacy.
Mechanism:
Induction of CYP3A4 enzymes.
Most likely new formulation: Improved transdermal delivery systems for chronic pain management (Year: 2026, 60% confidence)
Based on current usage trends and safety profile, sufentanil is likely to maintain its approved status for surgical analgesia.
Opioid Analgesic, Phenylpiperidine Derivative
Phenylpiperidine