Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Clinoril
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. It's a prodrug, meaning it's inactive until metabolized by the body into its active form, sulfide. Sulindac belongs to the arylalkanoic acid class of NSAIDs and works by inhibiting cyclooxygenase (COX) enzymes, which are involved in producing prostaglandins, substances that contribute to pain and inflammation.
For pain, fever, and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder, and gout.
All NSAIDs, including sulindac, carry a risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. They also have a risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Patients with a prior history of peptic ulcer disease or GI bleeding and elderly patients are at greater risk for serious gastrointestinal events.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Both drugs inhibit platelet function and can irritate the stomach lining.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Both alcohol and sulindac can irritate the stomach lining.
Outcome:
May reduce sulindac absorption
Mechanism:
Antacids can alter stomach pH, affecting drug absorption.
Most likely new formulation: sustained-release capsule (Year: 2026, 70% confidence)
Based on recent adverse event reports and ongoing clinical trials, there is a <1% likelihood of a black box warning update within the next year.
NSAID, Analgesic, Antipyretic, Anti-inflammatory
Arylalkanoic Acid