Medicines
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Discover all available medicines and treatments
Brand: Belsomra
Suvorexant is a small molecule orexin receptor antagonist used to treat insomnia. It works by blocking the binding of orexin neuropeptides to their receptors, which reduces wakefulness and promotes sleep. It is classified as a hypnotic and belongs to the pyrazine carboxamide class of compounds.
For the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Outcome:
Increased sedation and impairment
Mechanism:
Additive CNS depression
Outcome:
Increased suvorexant levels
Mechanism:
Inhibition of suvorexant metabolism
Outcome:
Decreased suvorexant levels
Mechanism:
Induction of CYP3A4
Most likely new formulation: extended-release formulation for improved sleep maintenance (Year: 2026, 70% confidence).
Based on current usage trends and safety profile, suvorexant is likely to maintain its current FDA approval status (95% confidence).
Hypnotic, Orexin Receptor Antagonist
Pyrazine Carboxamide