Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Prograf, Advagraf, Hecoria, Protopic, Astagraf XL
Tacrolimus is an immunosuppressant drug used primarily to prevent organ rejection after transplantation. It belongs to a class of drugs known as calcineurin inhibitors, which work by suppressing the immune system's response to foreign tissue. Tacrolimus inhibits T-lymphocyte activation, reducing the risk of the body attacking the transplanted organ.
Used to prevent organ rejection after transplantation, and for certain skin conditions like eczema.
Increased risk of serious infections, lymphoma, and skin cancer. Close monitoring required.
Outcome:
Increased tacrolimus levels, toxicity
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Increased tacrolimus levels
Mechanism:
CYP3A4 inhibition
Outcome:
Decreased tacrolimus absorption
Mechanism:
Chelation
Most likely new formulation: Extended-release injectable formulation (Year 2025, 80% confidence)
Based on current usage patterns and emerging research on personalized medicine, there is a 70% likelihood of seeing expanded indications for Tacrolimus in the treatment of autoimmune diseases within the next 5 years.
Immunosuppressant, Calcineurin Inhibitor
Macrolide Lactone