Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Cialis, Adcirca, Alyq
Tadalafil is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It works by relaxing the smooth muscles in the blood vessels, which increases blood flow to certain areas of the body.
For treating erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
Outcome:
Severe hypotension
Mechanism:
Synergistic vasodilation
Outcome:
Increased tadalafil levels
Mechanism:
Inhibition of CYP3A4
Outcome:
Slightly decreased tadalafil absorption
Mechanism:
Altered gastric pH
Most likely new formulation: Controlled-release implant for long-term treatment of ED (Year: 2028, 60% confidence).
Based on current usage trends and clinical trial data, there is a low likelihood of regulatory changes regarding tadalafil's approved indications in the next 2 years (85% confidence).
Phosphodiesterase-5 (PDE5) Inhibitor
Pyrazinopyridoindole-dione