Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zelnorm
Tegaserod is a 5-HT<sub>4</sub> receptor partial agonist that was used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in women. It works by stimulating the peristaltic reflex in the gut, increasing motility and reducing visceral sensitivity. It was withdrawn from the market due to cardiovascular safety concerns.
Used for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in women.
Outcome:
Increased tegaserod levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Decreased tegaserod levels
Mechanism:
Induction of CYP3A4 metabolism
Outcome:
Slight decrease in tegaserod absorption
Mechanism:
Changes in gastric pH
It is unlikely to see new formulations of tegaserod itself; however, research into more selective 5-HT<sub>4</sub> agonists with improved safety profiles is possible (Low Confidence).
Due to its withdrawal, there is a 0% likelihood of tegaserod being reintroduced to the market in its current form.
Serotonin Receptor Agonist, Gastroprokinetic Agent
Indole derivative