Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Temodar
Temozolomide is an alkylating agent, a type of chemotherapy drug, used primarily in the treatment of certain types of brain tumors, including glioblastoma multiforme (GBM) and anaplastic astrocytoma. It works by damaging the DNA of cancer cells, preventing them from growing and dividing. Temozolomide is administered orally and is readily absorbed, allowing it to cross the blood-brain barrier, which is crucial for treating brain tumors.
Used to treat certain types of brain tumors, such as glioblastoma and anaplastic astrocytoma.
Myelosuppression (decreased white blood cell, red blood cell, and platelet counts) can occur. Risk of secondary malignancies, including myelodysplastic syndrome and acute myeloid leukemia.
Outcome:
Decreased temozolomide clearance
Mechanism:
Inhibition of temozolomide metabolism
Outcome:
Potential for increased liver toxicity
Mechanism:
Additive hepatic stress
Outcome:
May slightly reduce temozolomide absorption
Mechanism:
Changes in gastric pH
Most likely new formulation: Extended-release temozolomide (2026, 80% confidence)
Based on current clinical trial data and usage trends, there is a 70% likelihood of expanded indications for temozolomide in other cancer types within the next 5 years.
Alkylating Agent, Imidazotetrazine Derivative
Imidazotetrazinone