Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Torisel
Temsirolimus is an intravenous (IV) drug used to treat advanced renal cell carcinoma (RCC), a type of kidney cancer. It's a targeted therapy that works by inhibiting mTOR, a protein that plays a key role in cell growth and division. By blocking mTOR, temsirolimus helps slow or stop the growth and spread of cancer cells.
Treatment of advanced renal cell carcinoma (RCC).
Increased risk of serious infections, hypersensitivity reactions, hyperglycemia/hyperlipidemia, impaired wound healing, and non-infectious pneumonitis. May cause fetal harm.
Outcome:
Increased temsirolimus levels, increased risk of side effects
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Potential increased liver toxicity
Mechanism:
Both drugs metabolized by the liver
Outcome:
Potential decreased temsirolimus absorption
Mechanism:
Changes in stomach pH
Most likely new formulation: Nanoformulation for improved delivery (Year: 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of continued approval for RCC with potential expansion to other cancer types.
Antineoplastic Agent, mTOR Inhibitor
Sirolimus Analog