Medicines
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Discover all available medicines and treatments
Brand: Kuvan, Biopten
Tetrahydrobiopterin (BH4) is a naturally occurring essential cofactor for several enzymes, including aromatic amino acid hydroxylases and nitric oxide synthases. It plays a crucial role in the synthesis of neurotransmitters like dopamine, serotonin, and norepinephrine, as well as in nitric oxide production, which is important for vascular function. BH4 is used to treat phenylketonuria (PKU) and tetrahydrobiopterin deficiency.
For the treatment of phenylketonuria (PKU) and tetrahydrobiopterin deficiency.
Outcome:
Severe hypotension
Mechanism:
Synergistic vasodilation
Outcome:
Increased risk of bleeding
Mechanism:
Additive effects on platelet function
Outcome:
Reduced absorption of tetrahydrobiopterin
Mechanism:
Changes in gastric pH
Most likely new formulation: sustained-release BH4 for improved patient compliance (Year: 2026, 80% confidence).
Based on current clinical trial data and increasing diagnoses, BH4 analogs have a 75% likelihood of expanded approval for other metabolic disorders by 2028.
Enzyme Cofactor, Antihyperphenylalaninemic Agent
Pteridine Derivative