Medicines
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Brand: Skelid
Tiludronate disodium is a bisphosphonate medication used to treat Paget's disease of bone, a disorder characterized by excessive bone breakdown and formation. It belongs to the class of drugs known as bisphosphonates, which work by inhibiting osteoclast activity, the cells responsible for bone resorption. This helps to normalize bone turnover and reduce the pain and complications associated with Paget's disease.
For treatment of Paget's disease of bone.
Outcome:
Increased risk of gastrointestinal irritation
Mechanism:
Additive effect on gastric mucosa
Outcome:
Reduced tiludronate absorption
Mechanism:
Chelation
Outcome:
Reduced tiludronate absorption
Mechanism:
Chelation
Most likely new formulation: None anticipated (0% confidence).
Based on current usage patterns and emerging therapies, there is a low ( <5%) likelihood of regulatory changes in the near future.
Bisphosphonate
Bisphosphonate