Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zanaflex, Sirdalud, Ternelin
Tizanidine is a centrally acting alpha-2 adrenergic agonist used as a muscle relaxant to treat spasticity. It works by decreasing the release of excitatory neurotransmitters in the spinal cord, reducing muscle tone and spasms. It is commonly prescribed for conditions like multiple sclerosis, cerebral palsy, and spinal cord injuries. Tizanidine belongs to the class of imidazoline derivatives.
For reducing muscle spasticity associated with multiple sclerosis, cerebral palsy, and spinal cord injuries.
Outcome:
Increased tizanidine levels and side effects
Mechanism:
Inhibition of CYP1A2 metabolism
Outcome:
Increased sedation and dizziness
Mechanism:
Additive CNS depressant effects
Outcome:
May slightly delay absorption
Mechanism:
Delayed gastric emptying
Most likely new formulation: Extended-release tizanidine patch (Year 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of tizanidine remaining a first-line treatment for spasticity over the next 5 years.
Muscle Relaxant, Alpha-2 Adrenergic Agonist
Imidazoline Derivative