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Discover all available medicines and treatments
Brand: Tasmar
Tolcapone is a selective, reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme that plays a crucial role in the metabolism of dopamine. It is used as an adjunct to levodopa/carbidopa in the management of Parkinson's disease, specifically for patients experiencing motor fluctuations (wearing-off phenomenon). By inhibiting COMT, tolcapone prolongs the duration of action of levodopa, leading to improved motor control and reduced off-time.
Used as an adjunct to levodopa/carbidopa in Parkinson's disease patients experiencing motor fluctuations.
Severe liver injury, including fatal cases, has been reported with tolcapone. Liver monitoring is required.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Increased tolcapone levels
Mechanism:
Inhibition of tolcapone metabolism
Outcome:
Decreased tolcapone absorption
Mechanism:
Chelation with tolcapone
Most likely new formulation: Extended-release tolcapone (2025, 60% confidence)
Based on current usage trends and safety profile, there is a 15% likelihood of increased regulatory scrutiny regarding liver monitoring protocols within the next 2 years.
COMT Inhibitor, Antiparkinsonian Agent
Nitrocatechol