Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Tolectin, Tolectin DS, Tolectin 600
Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation. It works by inhibiting cyclooxygenase (COX), an enzyme responsible for producing prostaglandins, which mediate pain and inflammation. Tolmetin is available in both immediate-release and extended-release formulations.
For relief of pain, fever, and inflammation associated with osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, and ankylosing spondylitis.
Tolmetin, like all NSAIDs, may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. Tolmetin is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events.
Outcome:
Increased bleeding risk
Mechanism:
Tolmetin displaces warfarin from protein binding sites, increasing free warfarin levels.
Outcome:
Increased risk of GI bleeding
Mechanism:
Additive effects on platelet inhibition and gastric irritation.
Outcome:
Reduced tolmetin absorption
Mechanism:
Antacids can interfere with tolmetin absorption.
Most likely new formulation: Topical formulation for localized pain relief (Year: 2025, 60% confidence)
Based on current usage trends and safety profile, there is a low probability of regulatory changes in the next 5 years (less than 10% likelihood).
Nonsteroidal anti-inflammatory drug (NSAID)
Pyrroleacetic acid derivative